Mechanism Of Action Of Paracetamol

• Acts on the hypothalamus to produce an antipyretic effect, as fever develops when the hypothalamus is set to a higher-than-normal temperature.
• May work peripherally to block pain impulse generation; may also inhibit prostaglandin synthesis in CNS

Therapeutic Indications Of Panadol Advance Tablets

• Headache: a very common condition that most people will experience many times during their lives. The main symptom of a headache is pain in your head or face. This can be throbbing, constant, sharp, or dull.
• Period pain
• Backache
• Rheumatic pain (joints pain)
• Cold and flu
• Sore throat
• Mild arthritis pain (joints pain)
• Muscle Pain
• Toothache
• Fever: a temporary increase in your body temperature. 

Undesirable Side Effects Of Panadol Advance Tablets

• Although it may be rare, some patients may experience undesirable side effects:

1. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with
2. or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
3. Signs of breathing problems like difficulty breathing. These signs are more likely to happen if you have previously experienced them after taking similar painkiller medications like aspirin and ibuprofen.
4. Sudden weight loss, nausea, yellowing of the skin and eyes, and loss of appetite.
5. Unexplained bleeding or bruising 

Pregnancy & Breastfeeding Precaution While Taking Panadol Advance Tablets

• Talk to your doctor if you are pregnant, plan on getting pregnant, or are breastfeeding. Make sure to discuss the risks and benefits that the medication can impose on you and the baby when you are pregnant.
• This medication is safe to take during breastfeeding

Non-Pharmacological Treatments & Advice

• You can also find the following Non-Pharmacological treatments effective in managing fever:

1. Baths
2. Cold compresses
3. encouraging fluid intake
4. ice packs
5. cooled blankets
6. room ventilation.

Warnings & Special Precautions While Taking Panadol Advance Tablets

• Do not take Paracetamol:

1. If you are allergic to Paracetamol, or any of the ingredients in this medicine.
2. Tell your doctor about the allergy and what signs you had.
3. If you are taking other Paracetamol-containing products. Make sure not to exceed the dose

• Talk to your doctor or pharmacist if you develop allergic reactions such as shortness of breath, skin rash, swelling of the face or neck, decreased blood pressure and dizziness.
• Make sure to tell your doctor if you have liver or kidney problems, including alcoholic liver disease or if you have mild arthritis (joints inflammation) and need to take painkillers daily.
• Long-term use of this medication may be harmful to your liver.
• Contact your doctor if symptoms are not relieved.
• Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medications like:

1. If you are taking metoclopramide or domperidone (used for vomiting or nausea).
2. If you are taking cholestyramine (used to lower blood cholesterol).
3. If you are taking blood-thinning medications (e.g. warfarin) and you need to take a painkiller every day.
4. Concomitant chronic use of painkillers and blood-thinning medications may increase the risk of bleeding.
5. If you are taking other Paracetamol-containing medications.